My master's research project (1.5 years) at IISER Kolkata was focused on the topic "Radical Chemistry". I have learned many aspects of the research field like the principles of photo-catalysts design and carry out photocatalyzed reactions. I also studied and actively worked in other field of organic chemistry including C-H activation and amino acid modification. I was directly involved with the project "selective trifluoromethylation of organic compounds from nucleophilic trifluoromethylating source".
Relevent Publications:
1) Recent Advances on Amino Acid Modifications via C-H Functionalization and Decarboxylative functionalization Strategies.
S. Mondal; S. Chowdhury* Adv. Synth. Catal, 2018, 360, 1884-1912
2) Visible-light mediated trifluoromethylation of p-quinone methides by 1,6-conjugate addition using pyrylium salt as an organic photocatalyst; K. G. Ghosh, C. Pallasetty, S. Mondal, Sureshkumar*. D; Tetrahedron. 2019, 75, 4471 - 4478
Relevent Publications:
1) Recent Advances on Amino Acid Modifications via C-H Functionalization and Decarboxylative functionalization Strategies.
S. Mondal; S. Chowdhury* Adv. Synth. Catal, 2018, 360, 1884-1912
2) Visible-light mediated trifluoromethylation of p-quinone methides by 1,6-conjugate addition using pyrylium salt as an organic photocatalyst; K. G. Ghosh, C. Pallasetty, S. Mondal, Sureshkumar*. D; Tetrahedron. 2019, 75, 4471 - 4478
Visible light photocatalysis
1) Importance of Fluorination & Trifluoromethylation
C-F and C-CF3 bonds have an integral role in pharmacuticals, agrochemicals, and materials. Because of high electronegativity of F atom, it can alter almost all physical properties of a molecule. Approximately 30% of all agrochemicals and 20% phermaceuticals contain fluorine (2005 study).
Despite importance of fluorine and more than 100 years of organofluorine chemistry, C-F and C-CF3 bond formation are still chalenging. With other difficulties associated with that one of the main reason is the availabilty of fluorinating reagents. The number of reagent avaialble (fluorination, trifluoromethylation) are less. In case of trifluoromethylation, few electrophilic and nucleophilic reagents are available. Among them electrophilic trifluoromethylation reagents are most popular as those reagents are more reactive than it's nucleophilic congeners. Most of the electrophilic reagents are very expensive and labour intensive to synthesize.
Our primary goals was to develop new methodology for trifluoromethylation using cheap commercially available nucleophilic trifluoromethylating reagent (example; CF3SO2Na)
Despite importance of fluorine and more than 100 years of organofluorine chemistry, C-F and C-CF3 bond formation are still chalenging. With other difficulties associated with that one of the main reason is the availabilty of fluorinating reagents. The number of reagent avaialble (fluorination, trifluoromethylation) are less. In case of trifluoromethylation, few electrophilic and nucleophilic reagents are available. Among them electrophilic trifluoromethylation reagents are most popular as those reagents are more reactive than it's nucleophilic congeners. Most of the electrophilic reagents are very expensive and labour intensive to synthesize.
Our primary goals was to develop new methodology for trifluoromethylation using cheap commercially available nucleophilic trifluoromethylating reagent (example; CF3SO2Na)
