(Reverse Chronology)
Quantum Materials Science
Supervised by : Dr. Yoshinori Okada
Associate Professor: Okinawa Institute of Science and Technology (OIST ), Japan
Group's Research Area : Quantum materials, 2D materials and superconductive materials
Duration of work : May 2019-Aug 2019
I explored the topic "Development of magnetic metal with van der Waals structure" . Van der Walls (vdW) material are those materials, which has the vander walls gap/ vdW plane(s) inside their unit cell. I was collaborating with Dr. Ryutaro Okuma (PhD, University of Tokyo), a postdoc member at the group on this project.
Materials with vdW coupling are particularly appealing due to their compatibility with advanced technologies, including single-particle spectroscopies and top-down device fabrication approaches. Our specific interest lay in magnetic vdW materials, a category that is highly rare. We aimed to explore the interplay between magnetism and highly conducting atomic sheets, a crucial aspect in the development of fast-electronics devices. A notable example of a vdW material in the electronics industry is graphene.
In the initial phase of the project, my responsibilities included growing single crystals of CeSiI and related materials using the Flux Method. Subsequently, I characterized these materials through powdered XRD and SEM-EDX. As of September 16, 2019, the ongoing phases involve band structure calculations using STM and ARPES in their respective units.
Associate Professor: Okinawa Institute of Science and Technology (OIST ), Japan
Group's Research Area : Quantum materials, 2D materials and superconductive materials
Duration of work : May 2019-Aug 2019
I explored the topic "Development of magnetic metal with van der Waals structure" . Van der Walls (vdW) material are those materials, which has the vander walls gap/ vdW plane(s) inside their unit cell. I was collaborating with Dr. Ryutaro Okuma (PhD, University of Tokyo), a postdoc member at the group on this project.
Materials with vdW coupling are particularly appealing due to their compatibility with advanced technologies, including single-particle spectroscopies and top-down device fabrication approaches. Our specific interest lay in magnetic vdW materials, a category that is highly rare. We aimed to explore the interplay between magnetism and highly conducting atomic sheets, a crucial aspect in the development of fast-electronics devices. A notable example of a vdW material in the electronics industry is graphene.
In the initial phase of the project, my responsibilities included growing single crystals of CeSiI and related materials using the Flux Method. Subsequently, I characterized these materials through powdered XRD and SEM-EDX. As of September 16, 2019, the ongoing phases involve band structure calculations using STM and ARPES in their respective units.
Chemistry and Chemical-Bio Engineering
Supervided by : Dr. Fujie Tanaka
Professor : Okinawa Institute of Science and Technology (OIST), Japan
Formerly Asscociate Professor : The Scripps Research Institute, USA
Group's Research Area : Synthetic Organic Chemistry, Bioorganic Chemistry
Duration of work : Jan 2019 - April 2019
Professor : Okinawa Institute of Science and Technology (OIST), Japan
Formerly Asscociate Professor : The Scripps Research Institute, USA
Group's Research Area : Synthetic Organic Chemistry, Bioorganic Chemistry
Duration of work : Jan 2019 - April 2019
I worked on the topic "Reactions of pyruvates: organocatalytic aldol and related reactions of pyruvates". Pyruvates can act as nucleophiles and electrophiles. Thus are expected to be useful synthons for numerous type of reactions. However, the dual reactivities of pyruvates are often difficult to control, especially in the reactions of simple pyruvates such as ethyl pyruvate and methyl pyruvate. In these study, we investigated to find new methodology using simple pyruvates under organo-catalysis condition to gain access to new complex molecular structure.
Supervised by : Dr. Paola Laurino
Associate Professor: Okinawa Institute of Science and Technology (OIST ), Japan
Group's Research Area : Protein Engineering and Evolution, Bio-catalysis
Duration of work : Sept 2018-Dec 2018
Associate Professor: Okinawa Institute of Science and Technology (OIST ), Japan
Group's Research Area : Protein Engineering and Evolution, Bio-catalysis
Duration of work : Sept 2018-Dec 2018
Worked on the topic title as "Synthesis of cell permeable derivative of S-adenosyl-L-methionine (AdoMet) ". AdoMet molecule serves as major methyl donor in nature in the presence of different enzymes. how does it do that? well If you look the structure of AdoMet (provided in right side), you will notice a CH3-S bond and because of (+)ve charge on S atom, it is extremely electrophilic. In presence of particular enzyme AdoMet molecule transfer its methyl to its substrate via SN2 pathway. This Methylation is associated with controlling various biological functions like DNA modification, epigenetic regulation. AdoMet molecule synthesized from ATP and L-methionine in presence of methionine adenosyltransferase (MAT) inside the cell. To work in the lab with AdoMet molecule and study related function in cell is challenging as the molecule readily degrade in physiochemical condition, also very less permeable in the cell wall. We looked up into these challenge, and hypothesize one chemically synthesized Glyco-derivative of natural AdoMet might solve these issues, i,e the synthesized AdoMet will be more stable in physiochemical condition and permeable in the cell wall compare to natural AdoMet. Synthesized two different Glyco-AdoMet molecule and performed biological screening.
Organic synthesis & Cataysis Lab, IISER-K (MASTER'S THESIS WORK)
Supervised by : Dr. Devarajulu Sureshkumar
Associate Professor : Indian Institute of Science Education and Research (IISER), Kolkata
Group's Research Area : Photo-redox catalysis, C-H bond activation, Synthetic organic chemistry.
Duration of work. : Aug 2016-June 2018
Associate Professor : Indian Institute of Science Education and Research (IISER), Kolkata
Group's Research Area : Photo-redox catalysis, C-H bond activation, Synthetic organic chemistry.
Duration of work. : Aug 2016-June 2018
- Worked on aspects of Visible Light Photoredox Catalysis. The project starts with hypothesizing to develop a new efficinet & cost effective methodology for selective trifluoromethylation. To achieve this goal, we used organo moiety (without metal) as a photoredox catalyst and CF3SO2Na as a trifluoromethyl source. This is followed by characterization with state-of-the-art spectroscopic techniques to understand the mechanism. (Published in Tetrahedron 2019)
- researched on TEMPO mediated organic reactions to synthesize five membered heterocyclic compounds. In this project, I used catalytic amount of TEMPO as a radical generator and inorganic oxidants to regenerate TEMPO. Using this methodology we can synthesize regioselectively three compounds of isoxazoline derivatives using TEMPO by radical mediated pathway. (Published in Chemistry an Asian Journal 2021)
Organic synthesis & Cataysis Lab, IISER-K
Project Title : Trifluoromethylation of organic compounds by C-H bond activation
Worked on the topic "Ligand directed Pd catalyzed Sp3C-H bond activation". Designed & Synthesized various natural α‑Amino Acids derivative in gram scale & characterized by NMR, Mass. Electrophilic trifluoromethylating reagents (Togni, Umemoto's reagent) was synthesized and used for this project. Our rationale behind this work was using strong oxidants & electrophilic reagents we can able to genarate Pd(II) to Pd(IV) complex which after reductive elimination deliver trifluoromethylated product.
Publication : Recent Advances on Amino Acid Modifications via C-H Functionalization and Decarboxylative functionalization Strategies. S. Mondal; S. Chowdhury* Adv. Synth. Catal, 2018
Publication : Recent Advances on Amino Acid Modifications via C-H Functionalization and Decarboxylative functionalization Strategies. S. Mondal; S. Chowdhury* Adv. Synth. Catal, 2018
Organic-Biophysical Chemistry Lab, IISER-K
Supervised by : Dr. Pradip Kumar Tarafdar
Associate Professor : Indian Institute of Science Education and Research (IISER), Kolkata
Group's Research Area : Lipid synthesis, Drug delivery, Membrane Trafficking
Research Internship duration: Oct 2015-Feb 2016
Associate Professor : Indian Institute of Science Education and Research (IISER), Kolkata
Group's Research Area : Lipid synthesis, Drug delivery, Membrane Trafficking
Research Internship duration: Oct 2015-Feb 2016
Worked on the topic "Lipid synthesis & Liposomal drug delivery". Synthesized various cationic lipid and mixing with appropiate negatively charged lipid, developed an unique self assemble nano structure (Vesicle). It was further characterized by SEM mesurements. Successfully Encapsulated drug and peformed in vitro pH responsive drug release study. Kinetic analysis was also done.
Publication : Headgroup linker perturbs pKa via acyl chain migration: Designing base-labile supramolecular assemblies, A. Sardar, N. K. Rout, S. Nath, M. Prasad, J. Mahanti, S. Mondal and P. K. Tarafdar* Chem. Commun., 2018
Publication : Headgroup linker perturbs pKa via acyl chain migration: Designing base-labile supramolecular assemblies, A. Sardar, N. K. Rout, S. Nath, M. Prasad, J. Mahanti, S. Mondal and P. K. Tarafdar* Chem. Commun., 2018
Supervised by : Dr. Debasish Halder
Professor : Indian Institute of Science Education and Research (IISER), Kolkata
Group's Research Area : Self-assembly of peptides and peptidomimetics, Stimuli responsive
foldamer, Peptide, based therapeutics, Peptide based nano-materials.
Research Internship duration : July 2015-Sept 2015
Professor : Indian Institute of Science Education and Research (IISER), Kolkata
Group's Research Area : Self-assembly of peptides and peptidomimetics, Stimuli responsive
foldamer, Peptide, based therapeutics, Peptide based nano-materials.
Research Internship duration : July 2015-Sept 2015
Worked on "Peptide Self-Assembly" aspects of supramolecular chemistry. Synthesized small chain (di & tri) peptide and characterized by NMR, Mass, IR . This was further characterized by SEM mesurements. Also had done research on how this self-assemble nano structure can be used as a therapeutic application.