I have joined Prof. Fujie Tanaka's group for my PhD study. I am working on the topic "how to control the dual reactivity of pyruvates ? and use pyruvates as nucleophile in the reaction". For more information about the topic, projects and findings please visit research interest (PhD study).
Supervised by : Dr. Yoshinori Okada Assistant Professor: Okinawa Institute of Science and Technology (OIST ), Japan Group's Research Area : Quantum materials, 2D materials and superconductive materials
Duration of work : May 2019-Aug 2019
I worked on the topic "Development of magnetic metal with van der Waals structure" . Van der Walls (vdW) material are those materials, which has the vander walls gap/ vdW plane(s) inside their unit cell. I was working with Dr. Ryutaro Okuma (PhD, University of Tokyo) on this project. vdW coupled materials are attractive because of their compatibility with recent advanced technologies, such as single particle spectroscopies and top down device fabrication approach. On the other side we were interested in magnetic vdW materials because, 1st of all it is highly rare and we think that we could interplay between magnetism and highly conducting atomic sheets which is currently important in fast-electronics devices. For an example graphene is a very good example of vdW material, which is highly valued material in electronic industry. My job was to grew single crystal of CeSiI and related materials in Flux Method. Then charecterized by powdered XRD and SEM-EDX. Next phase of the work, band structure calculation with STM and ARPES are currently undergoing in respective unit (as on 16-09-2019).
Chemistry and Chemical-Bio Engineering Unit, (Rotation 2)
Supervided by : Dr. Fujie Tanaka Associate Professor : Okinawa Institute of Science and Technology (OIST), Japan Formerly Asscociate Professor : The Scripps Research Institute, USA Group's Research Area : Synthetic Organic Chemistry, Bioorganic Chemistry
Duration of work : Jan 2019 - April 2019
I worked on the topic "Reactions of pyruvates: organocatalytic aldol and related reactions of pyruvates". Pyruvates can act as nucleophiles and electrophiles. Thus are expected to be useful synthons for numerous type of reactions.However, the dual reactivities of pyruvates are often difficult to control, especially in the reactions of simple pyruvates such as ethyl pyruvate and methyl pyruvate. In these study, we investigated to find new methodology using simple pyruvates under organo-catalysis condition to gain access to new complex molecular structure.
Supervised by : Dr. Paola Laurino Assistant Professor: Okinawa Institute of Science and Technology (OIST ), Japan Group's Research Area : Protein Engineering and Evolution study, Bio-catalysis
Duration of work : Sept 2018-Dec 2018
Worked on the topic title as "Synthesis of cell permeable derivative of S-adenosyl-L-methionine (AdoMet)". AdoMet molecule serves as major methyl donor in nature in the presence of different enzymes. how does it do that? well If you look the structure of AdoMet (provided in right side), you will notice a CH3-S bond and because of (+)ve charge on S atom, it is extremely electrophilic. In presence of particular enzyme AdoMet molecule transfer its methyl to its substrate via SN2 pathway. This Methylation is associated with controlling various biological functions like DNA modification, epigenetic regulation. AdoMet molecule synthesized from ATP and L-methionine in presence of methionine adenosyltransferase (MAT) inside the cell. To work in the lab with AdoMet molecule and study related function in cell is challenging as the molecule readily degrade in physiochemical condition, also very less permeable in the cell wall. We looked up into these challenge, and hypothesize one chemically synthesized Glyco-derivative of natural AdoMet might solve these issues, i,e the synthesized AdoMet will be more stable in physiochemical condition and permeable in the cell wall compare to natural AdoMet. Synthesized two different Glyco-AdoMet molecule. Biological assay of these project currently undergoing.
Master's Thesis Project
Organic synthesis & Cataysis Lab, IISER-K
Supervised by : Dr. Devarajulu Sureshkumar Assistant Professor : Indian Institute of Science Education and Research (IISER), Kolkata Group's Research Area : Asymmetric halogenation, Photo-redox catalysis, C-H bond activation, Synthetic organic chemistry.
Duration of work. : Aug 2016-June 2018
Worked on aspects of Visible Light Photoredox Catalysis. The project starts with hypothesizing to develop a new efficinet & cost effective methodology for selective trifluoromethylation, to achieve this goal used organo moiety as a photoredox catalyst and CF3SO2Na as trifluoromethyl source. This is followed by characterization with state-of-the-art spectroscopic techniques to understand the mechanism. (Published in Tetrahedron 2019)
Also worked on TEMPO mediated organic transformation to synthesize valuable heterocyclic compounds. In this project used catalytic amount of TEMPO as radical generator and a inorganic oxidant to regenerate TEMPO. By these useful methodology we can synthesize regioselectively three compound of isoxazoline derivatives using TEMPO by radical mediated pathway. (full work will be published soon)
Project Title : Trifluoromethylation of organic compounds by C-H bond activation
Worked on the topic "Ligand directed Pd catalyzed Sp3C-H bond activation". Designed & Synthesized various natural α‑Amino Acids derivative in gram scale & characterized by NMR, Mass. Used mainly electrophilic trifluoromethylating reagents (Togni, Umemoto's reagent) for this project. Our rationale behind this work was using strong oxidants & electrophilic reagents we can able to genarate Pd(II) to Pd(IV) complex which after reductive elimination gives rise to trifluoromethylated product. Also synthesized Togni reagents and enantiometrically pure bicycle[2.2.2] octadiene ligand in gram scale. Publication : Recent Advances on Amino Acid Modifications via C-H Functionalization and Decarboxylative functionalization Strategies. S. Mondal; S. Chowdhury* Adv. Synth. Catal,2018
Organic-Biophysical Chemistry Lab, IISER-K
Supervised by : Dr. Pradip Kumar Tarafdar Assistant Professor : Indian Institute of Science Education and Research (IISER), Kolkata Group's Research Area : Lipid synthesis, Drug delivery, Membrane Trafficking Research Internship duration: Oct 2015-Feb 2016
Worked on the topic "Lipid synthesis & Liposomal drug delivery". Synthesized various cationic lipid and mixing with appropiate negatively charged lipid part developed a unique self assemble nano structure (Vesicle). It was further characterized by SEM mesurements. Successfully Encapsulated drug & done in vitro pH responsive drug release study. Also done kinetic study for release of drug.
Publication : Headgroup linker perturbs pKa via acyl chain migration: Designing base-labile supramolecular assemblies,A. Sardar, N. K. Rout, S. Nath, M. Prasad, J. Mahanti, S. Mondal and P. K. Tarafdar* Chem. Commun., 2018
Supervised by : Dr. Debasish Halder Professor : Indian Institute of Science Education and Research (IISER), Kolkata Group's Research Area : Self-assembly of peptides and peptidomimetics, Stimuli responsive foldamer, Peptide, based therapeutics, Peptide based nano-materials.
Research Internship duration : July 2015-Sept 2015
Worked on "Peptide Self-Assembly" aspects of supramolecular chemistry. Synthesized small chain (di & tri) peptide and characterized by NMR, Mass, IR . This was further characterized by SEM mesurements. Also had done research on how this self-assemble nano structure can be used as a therapeutic application.